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Cathepsin B

Cathepsin B信息

英文名称:Cathepsin B上市药物数量0
中文名称组织蛋白酶B临床药物数量1
靶点别称EC 3.4.22，EC:3.4.22.1，RECEUP，Cathepsin B，Amyloid Precursor Protein Secretase，Epididymis Secretory Sperm Binding Protein，Cathepsin B1，Cysteine Protease，EC 3.4.22.1，CPSB，APPS，APP secretase，CTSB最高研发阶段临床二期
英文名称:Cathepsin B
中文名称组织蛋白酶B
靶点别称EC 3.4.22，EC:3.4.22.1，RECEUP，Cathepsin B，Amyloid Precursor Protein Secretase，Epididymis Secretory Sperm Binding Protein，Cathepsin B1，Cysteine Protease，EC 3.4.22.1，CPSB，APPS，APP secretase，CTSB
上市药物数量0
临床药物数量1
最高研发阶段Phase 2 Clinical

Cathepsin B产品列表

  • 属性

    Protein (2)

  • 产品库

    在线 (2)

  • 物种

    Human (1)Mouse (1)

  • 标签

    His Tag (2)

  • 标记

    Unconjugated (2)

共 2 项数据
  • 1

Cathepsin B分子背景

Cathepsin B (CTSB) is also known as APP secretase (APPS) and CPSB, is an enzymatic protein belonging to the peptidase C1 family. Cathepsin B / CTSB is synthesized as a preproenzyme. Following removal of the signal peptide, the inactive proenzyme undergoes further modifications including removal of the pro region to result in the active enzyme. The catalytic activity of Cathepsin B / APPS contains: Hydrolysis of proteins with broad specificity for peptide bonds; Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L); In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides. As a thiol protease, cathepsin B / CPSB is believed to participate in intracellular degradation and turnover of proteins and has also been implicated in tumor invasion and metastasis. Overexpression of cathepsin B has been associated with esophageal adenocarcinoma and other tumors.

Cathepsin B分子别名

CTSB,CPSB,APPS

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  • 分子信息
  • 产品列表