自身免疫性疾病靶点与药物研发
自身免疫性疾病（Autoimmune disease, AID）指人体免疫系统因打破自身免疫耐受而出现异常，进而攻击自身器官、组织或细胞，引起损伤所产生的一类疾病。
根据影响器官和组织的范围，AID可分为器官特异性AID和非器官特异性AID。器官特异性AID是指病变局限于某一特定器官或组织，如多发性硬化症、自身免疫性肝病、l型糖尿病等。非器官特异性AID是指侵犯多种组织器官或系统的一组疾病，包括系统性红斑狼疮、类风湿关节炎、强直性脊柱炎、干燥综合征、多发性肌炎、皮肌炎等。
ACROBiosystems持续专注为生物医药用户提供更加全面的药物开发工具。为满足自身免疫性疾病药物开发需求，ACROBiosystems针对疾病靶点开发了高质量重组蛋白、功能细胞株、抗体及试剂盒等产品，适用生物药开发不同阶段，全面助力您的药物开发进程！
自身免疫性疾病导览
热门自免疾病药物开发工具
参考文献
- 1. ZHU Yu-yu, SONG Cheng-lin, SUN Yang. Advances in mechanisms for psoriasis and drug regulation. Acta Pharmaceutica Sinica, 2020, 55(7): 1393-1400.
- 2. Fuschiotti P. Current perspectives on the immunopathogenesis of systemic sclerosis. Immunotargets Ther. 2016;5:21-35 .
- 3. Dalakas MC, Hohlfeld R. Polymyositis and dermatomyositis. Lancet. 2003 Sep 20;362(9388):971-82.
- 4. Roda, G., Chien Ng, S., Kotze, P.G. et al. Crohn’s disease. Nat Rev Dis Primers 6, 22 (2020).
- 5. Ordás I, Eckmann L, Talamini M, Baumgart DC, Sandborn WJ. Ulcerative colitis. Lancet. 2012 Nov 3;380(9853):1606-19.
- 6. Cervantes-Gracia, K., Husi, H. Integrative analysis of Multiple Sclerosis using a systems biology approach. Sci Rep 8, 5633 (2018).
- 7. Gilhus, N.E., Tzartos, S., Evoli, A. et al. Myasthenia gravis. Nat Rev Dis Primers 5, 30 (2019).
- 8. Zajec A, Trebušak Podkrajšek K, Tesovnik T, Šket R, Čugalj Kern B, Jenko Bizjan B, Šmigoc Schweiger D, Battelino T, Kovač J. Pathogenesis of Type 1 Diabetes: Established Facts and New Insights. Genes (Basel). 2022 Apr 16;13(4):706.
- 9. Inui N, Sakai S, Kitagawa M. Molecular Pathogenesis of Pulmonary Fibrosis, with Focus on Pathways Related to TGF-β and the Ubiquitin-Proteasome Pathway. Int J Mol Sci. 2021 Jun 5;22(11):6107.
- 10. Montero, P.; Milara, J.; Roger, I.; Cortijo, J. Role of JAK/STAT in Interstitial Lung Diseases; Molecular and Cellular Mechanisms. Int. J. Mol. Sci. 2021, 22, 6211.
- 11. Zhu, M.; Ding, Q.; Lin, Z.; Fu, R.; Zhang, F.; Li, Z.; Zhang, M.; Zhu, Y. New Targets and Strategies for Rheumatoid Arthritis: From Signal Transduction to Epigenetic Aspect. Biomolecules 2023, 13, 766.
- 12. Batu, Ezgi. (2018). Monogenic systemic lupus erythematosus: insights in pathophysiology. Rheumatology International. 38. 10.1007/s00296-018-4048-7.
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- 自身免疫性疾病导览
- 热门自免疾病药物开发工具
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