免费注册

EDNRB

EDNRB信息

英文名称:Endothelin receptor type B上市药物数量5
中文名称内皮素B受体临床药物数量3
靶点别称Hirschsprung Disease 2，Endothelin receptor non-selective type，ET-B，Endothelin receptor type B，EDNRB，ET-BR，ETRB，Endothelin Receptor Subtype B1，ABCDS，HSCR2，ETB1，ETBR，WS4A，HSCR，ETB，Receptor， Endothelin B最高研发阶段批准上市
英文名称:Endothelin receptor type B
中文名称内皮素B受体
靶点别称Hirschsprung Disease 2，Endothelin receptor non-selective type，ET-B，Endothelin receptor type B，EDNRB，ET-BR，ETRB，Endothelin Receptor Subtype B1，ABCDS，HSCR2，ETB1，ETBR，WS4A，HSCR，ETB，Receptor， Endothelin B
上市药物数量5
临床药物数量3
最高研发阶段Approved

EDNRB产品列表

  • 属性

    Protein (2)

  • 产品库

    在线 (2)

  • 物种

    Human (2)

  • 标签

  • 标记

    Unconjugated (1)GFP Fusion (1)

共 2 项数据
  • 1

EDNRB分子背景

Endothelin Receptor B (EDNRB) is a type of G protein-coupled Receptor with the N-terminus located outside the cell. It's widespread in the human body. EDNRB binds to ET and transmits information into the cell through the intracellular Ca2+ phospholipid-dependent protein kinase second messenger system, which promotes the rapid release of calcium in the endoplasmic reticulum and sarcoplasmic reticulum, resulting in the rapid increase of intracellular calcium concentration. Endothelin exerts its biological effects through its receptor (ETR). Endothelin and ETR constitute the endothelin axis. Endothelin axis has pro-tumor effects in various tumors including malignant melanoma (MM), including promoting tumor growth, anti-apoptosis, promoting angiogenesis and promoting tumor metastasis.

EDNRB分子别名

EDNRB,endothelin receptor type B,ABCDS, ET-B, ET-BR, ETB, ETB1, ETBR, ETRB, HSCR, HSCR2, WS4A
  • 分子信息
  • 产品列表