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KRAS

KRAS信息

英文名称:V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog上市药物数量0
中文名称V-Ki-ras2 Kirsten大鼠肉瘤病毒癌基因同源蛋白临床药物数量23
靶点别称KRAS，V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog最高研发阶段临床二期
英文名称:V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
中文名称V-Ki-ras2 Kirsten大鼠肉瘤病毒癌基因同源蛋白
靶点别称KRAS，V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
上市药物数量0
临床药物数量23
最高研发阶段Phase 2 Clinical

KRAS产品列表

  • 属性

    Protein (10)

  • 产品库

    在线 (10)

  • 物种

    Human (10)

  • 标签

    His Tag (10)

  • 标记

    Unconjugated (10)

共 10 项数据
  • 1

KRAS分子背景

KRAS (Kirsten rat sarcoma 2 viral oncogene homolog) gene is a proto-oncogene that encodes a small GTPase transductor protein called KRAS. KRAS is also known as Ki-Ras, c-K-ras and c-Ki-ras. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation, promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner. RAS is one of the most frequently mutated oncogenes in human cancer but the frequency and distribution of RAS gene mutations are not uniform. In details, mutation of glycine 12 (G12) causes RAS activation by interfering with GAP binding and GAP-stimulated GTP hydrolysis. The reference shows the pathway may as a potential therapy targets.

KRAS分子别名

GTPase Kras,K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras,KRAS2,RASK2,C-K-RAS,CFC2,K-RAS2A,K-RAS2B,K-RAS4A,K-RAS4B,KI-RAS,KRAS1,KRAS2,NS,NS3,RASK2,KRAS
  • 分子信息
  • 产品列表