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E-Cadherin

E-Cadherin信息

英文名称:Cadherin-1上市药物数量0
中文名称钙粘蛋白-1临床药物数量0
靶点别称CAM 120/80，Epithelial cadherin，Ecad，Uvomorulin，CDHE，UVO最高研发阶段临床前
英文名称:Cadherin-1
中文名称钙粘蛋白-1
靶点别称CAM 120/80，Epithelial cadherin，Ecad，Uvomorulin，CDHE，UVO
上市药物数量0
临床药物数量0
最高研发阶段Preclinical

E-Cadherin产品列表

  • 属性

    Protein (2)

  • 产品库

    在线 (2)

  • 物种

    Human (2)

  • 标签

    Fc Tag (2)

  • 标记

    Unconjugated (2)

共 2 项数据
  • 1

E-Cadherin分子背景

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-1 (CDH1) is also known as epithelial cadherin (E-cadherin), CD_antigen (CD324), Uvomorulin (UVO) ECAD and CDHE, CDH1 / CD324 contains 5 cadherin domains. CDH1 / CD324 / ECAD is expressed in non-neural epithelial tissues. CDH1 / E-CAD is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells and has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad promotes non-amyloidogenic degradation of Abeta precursors and has a strong inhibitory effect on APP C99 and C83 production. Defects in CDH1 / CD324 / ECAD are the cause of hereditary diffuse gastric cancer (HDGC).

E-Cadherin分子别名

Cadherin-1,CDH1,CD324,E-cadherin,Arc-1,ECAD,LCAM,UVO
  • 分子信息
  • 产品列表