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ICAM-1

ICAM-1信息

英文名称:Intercellular adhesion molecule-1上市药物数量2
中文名称细胞间粘附分子-1临床药物数量2
靶点别称Intercellular Adhesion Molecule 1，Cell Surface Glycoprotein P3.58，Major group rhinovirus receptor，Human Rhinovirus Receptor，CD54 Antigen，P3.58，CD54，BB2，Intercellular Adhesion Molecule-1，ICAM1，ICAM-1，Intercellular Adhesion Molecule 1 (CD54)， Human Rhinovirus Receptor，Epididymis Secretory Sperm Binding Protein最高研发阶段批准上市
英文名称:Intercellular adhesion molecule-1
中文名称细胞间粘附分子-1
靶点别称Intercellular Adhesion Molecule 1，Cell Surface Glycoprotein P3.58，Major group rhinovirus receptor，Human Rhinovirus Receptor，CD54 Antigen，P3.58，CD54，BB2，Intercellular Adhesion Molecule-1，ICAM1，ICAM-1，Intercellular Adhesion Molecule 1 (CD54)， Human Rhinovirus Receptor，Epididymis Secretory Sperm Binding Protein
上市药物数量2
临床药物数量2
最高研发阶段Approved

ICAM-1产品列表

  • 属性

    Protein (4)

  • 产品库

    在线 (4)

  • 物种

    Human (3)Mouse (1)

  • 标签

    Fc Tag (1)His Tag (1)His Tag & Avi Tag (2)

  • 标记

    Unconjugated (2)Biotin-labeled (2)

共 4 项数据
  • 1

ICAM-1分子背景

Inter-Cellular Adhesion Molecule 1 (ICAM-1) is also known as Cluster of Differentiation 54 (CD54), is a member of the immunoglobulin superfamily, and is a cell surface glycoprotein which is typically expressed in low concentrations on endothelial cells and cells of the immune system. The protein encoded by this gene is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFα) and is expressed by the vascular endothelium, macrophages, and lymphocytes. ICAM-1 is a ligand for LFA-1 (integrin), a receptor found on leukocytes. When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 and then transmigrate into tissues. ICAM-1 has been implicated in subarachnoid hemorrhage (SAH). Levels of ICAM-1 are shown to be significantly elevated in patients with SAH over control subjects in many studies. ICAM-1 expressed by respiratory epithelial cells is also the binding site for rhinovirus, the causative agent of most common colds.

ICAM-1分子别名

ICAM1,BB2,CD54,P3.58
  • 分子信息
  • 产品列表