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SIRP alpha

SIRP alpha信息

英文名称:Signal-regulatory protein alpha上市药物数量2
中文名称信号调节蛋白α临床药物数量15
靶点别称SHPS-1，Macrophage fusion receptor，Brain Ig-like molecule with tyrosine-based activation motifs，MFR，Signal-regulatory protein alpha-1，Signal-regulatory protein alpha-2，CD172a，MyD-1 antigen，Sirp-alpha-3，MYD1，SIRPA，Signal Regulatory Protein Alpha，CD172 Antigen-Like Family Member A，Inhibitory Receptor SHPS-1，PTPNS1，SHPS1，SIRP，P84，Brain-Immunoglobulin-Like Molecule With Tyrosine-Based Activation Motifs，Protein Tyrosine Phosphatase， Non-Receptor Type Substrate 1，Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1，Tyrosine Phosphatase SHP Substrate 1，Signal-Regulatory Protein Alpha-3，Signal-Regulatory Protein Alpha，SHP Substrate 1，CD172a Antigen，Sirp-Alpha-1，Sirp-Alpha-2，MYD-1，Bit，SIRPalpha，SIRPalpha2最高研发阶段批准上市
英文名称:Signal-regulatory protein alpha
中文名称信号调节蛋白α
靶点别称SHPS-1，Macrophage fusion receptor，Brain Ig-like molecule with tyrosine-based activation motifs，MFR，Signal-regulatory protein alpha-1，Signal-regulatory protein alpha-2，CD172a，MyD-1 antigen，Sirp-alpha-3，MYD1，SIRPA，Signal Regulatory Protein Alpha，CD172 Antigen-Like Family Member A，Inhibitory Receptor SHPS-1，PTPNS1，SHPS1，SIRP，P84，Brain-Immunoglobulin-Like Molecule With Tyrosine-Based Activation Motifs，Protein Tyrosine Phosphatase， Non-Receptor Type Substrate 1，Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1，Tyrosine Phosphatase SHP Substrate 1，Signal-Regulatory Protein Alpha-3，Signal-Regulatory Protein Alpha，SHP Substrate 1，CD172a Antigen，Sirp-Alpha-1，Sirp-Alpha-2，MYD-1，Bit，SIRPalpha，SIRPalpha2
上市药物数量2
临床药物数量15
最高研发阶段Approved

SIRP alpha产品列表

  • 属性

    Protein (20)Cell (1)

  • 产品库

    在线 (21)

  • 物种

    Human (10)Mouse (6)Cynomolgus (4)Rat (1)

  • 标签

    His Tag (4)Fc Tag (5)Mouse IgG Fc Tag (2)Fc Tag & Avi Tag (3)His Tag & Avi Tag (3)Mouse IgG Fc Tag & Avi Tag (1)Llama IgG Fc Tag (2)

  • 标记

    Unconjugated (11)Biotin-labeled (7)PE Labeled (2)

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SIRP alpha分子背景

Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

SIRP alpha分子别名

SHPS1,SIRPA,CD172A,BIT,MFR,MYD1,P84,PTPNS1

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