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STAT3

STAT3信息

英文名称:Signal transducer and activator of transcription 3上市药物数量2
中文名称信号转导和转录激活因子-3临床药物数量19
靶点别称Acute-phase response factor，APRF，STAT3，Signal Transducer And Activator Of Transcription 3 (Acute-Phase Response Factor)，Signal transducer and activator of transcription 3，DNA-Binding Protein APRF，ADMIO1，ADMIO，HIES，STAT3 Transcription Factor最高研发阶段批准上市
英文名称:Signal transducer and activator of transcription 3
中文名称信号转导和转录激活因子-3
靶点别称Acute-phase response factor，APRF，STAT3，Signal Transducer And Activator Of Transcription 3 (Acute-Phase Response Factor)，Signal transducer and activator of transcription 3，DNA-Binding Protein APRF，ADMIO1，ADMIO，HIES，STAT3 Transcription Factor
上市药物数量2
临床药物数量19
最高研发阶段Approved

STAT3产品列表

  • 属性

    Cell (1)Protein (1)

  • 产品库

    在线 (2)

  • 物种

    Human (2)

  • 标签

    His Tag (1)

  • 标记

    Unconjugated (1)

共 2 项数据
  • 1

STAT3分子背景

Signal transducer and activator of transcription 3 (STAT3) regulates the expression of genes important for essential cellular processes including survival, proliferation, self-renewal, angiogenesis, and immune response. As an early tumor diagnostic marker, it is considered that constitutive STAT3 activation is a sufficient factor to cause malignant transformation and tumor development in model systems. The classical IL-6/STAT3 signaling pathway in cancer cells. IL-6 binds to the membrane-bound IL-6 receptor α (IL-6R) and IL-6 receptor β (also known as gp130). The IL-6/IL-6R/gp130 complex activate the phosphorylation of JAKs, followed by STAT3 phosphorylation and activation. Then, phosphorylated STAT3 forms a homodimer and translocates into the nucleus to bind to the promotor region of target genes and activates target gene transcription.

STAT3分子别名

STAT3, signal transducer and activator of transcription 3

产品评论

  • zh********imm.ac.cn 2024-10-31
    1人点赞
    Human STAT3 Protein, His Tag (MALS & SPR verified)
    蛋白质量很好，包装也很好，瓶子设计合理，一撕即开，销售人员服务态度超级好，有问题还会及时解答，不管是产品的问题，还是技术的问题，都回复的相当及时和准确，已经购买好多次了，期待以后还有其它方面的多多合作，实验结果也很理想，感谢销售人员！谢谢！
  • di********163.com 2023-03-14
    0人点赞
    Human STAT3 Protein, His Tag (MALS & SPR verified)
    产品很好，质量很高，服务态度好，真的非常期待再次合作。物流快，包装完好。实验结果也非常的符合实验预期的结果，还会再来的。
  • 分子信息
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