Human CD3 delta Protein, His Tag

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CDD-H5224-100ug
¥3310.00
CDD-H5224-1mg
¥18480.00
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产品信息

分子别名(Synonym)

CD3D,CD3-DELTA,T3D

表达区间及表达系统(Source)

Human CD3 delta, His Tag (CDD-H5224) is expressed from human 293 cells (HEK293). It contains AA Phe 22 - Ala 105 (Accession # P04234-1).

Predicted N-terminus: Phe 22

Request for sequence

蛋白结构(Molecular Characterization)

CD3 delta Structure

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 11.4 kDa. The protein migrates as 18-28 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.

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电泳(SDS-PAGE)

CD3 delta SDS-PAGE

Human CD3 delta, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

 

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背景

T-cell surface glycoprotein CD3 delta, also known as CD3D. CD3D, together with CD3- epsilon(CD3E) , CD3-gamma and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z.

前沿进展

 
靶点信息
  • 英文全称:

    T cell surface glycoprotein CD3

  • 中文全称:

    T细胞表面糖蛋白CD3复合体

  • 种类:

  • 上市药物数量:

    7 详情

  • 临床药物数量:

    157 详情

  • 最高研发阶段:

    临床三期

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