免费注册

CXCR4

CXCR4信息

英文名称:C-X-C motif chemokine receptor 4上市药物数量3
中文名称C-X-C基序趋化因子受体4临床药物数量23
靶点别称NPYRL，CD184，CXCR4，CXC-R4，SDF-1 receptor，LAP-3，Fusin，FB22，HM89，Seven-Transmembrane-Segment Receptor， Spleen，Chemokine (C-X-C Motif)， Receptor 4 (Fusin)，Seven Transmembrane Helix Receptor，C-X-C Chemokine Receptor Type 4，Neuropeptide Y Receptor Y3，Neuropeptide Y3 Receptor，Chemokine Receptor，D2S201E，HSY3RR，NPYY3R，CXCR-4，NPY3R，WHIMS，LAP3，NPYR，WHIM，Receptors， CXCR4，LCR1，LESTR，LPS-associated protein 3，Leukocyte-Derived Seven Transmembrane Domain Receptor，Stromal Cell-Derived Factor 1 Receptor，Chemokine (C-X-C Motif) Receptor 4，CD184 Antigen，C-X-C Motif Chemokine Receptor 4，Lipopolysaccharide-Associated Protein 3最高研发阶段批准上市
英文名称:C-X-C motif chemokine receptor 4
中文名称C-X-C基序趋化因子受体4
靶点别称NPYRL，CD184，CXCR4，CXC-R4，SDF-1 receptor，LAP-3，Fusin，FB22，HM89，Seven-Transmembrane-Segment Receptor， Spleen，Chemokine (C-X-C Motif)， Receptor 4 (Fusin)，Seven Transmembrane Helix Receptor，C-X-C Chemokine Receptor Type 4，Neuropeptide Y Receptor Y3，Neuropeptide Y3 Receptor，Chemokine Receptor，D2S201E，HSY3RR，NPYY3R，CXCR-4，NPY3R，WHIMS，LAP3，NPYR，WHIM，Receptors， CXCR4，LCR1，LESTR，LPS-associated protein 3，Leukocyte-Derived Seven Transmembrane Domain Receptor，Stromal Cell-Derived Factor 1 Receptor，Chemokine (C-X-C Motif) Receptor 4，CD184 Antigen，C-X-C Motif Chemokine Receptor 4，Lipopolysaccharide-Associated Protein 3
上市药物数量3
临床药物数量23
最高研发阶段Approved

CXCR4产品列表

  • 属性

    Protein (3)

  • 产品库

    在线 (5)

  • 物种

    Human (3)

  • 标签

    Fc Tag (1)His Tag & Flag Tag (1)

  • 标记

    Unconjugated (3)

共 3 项数据
  • 1

CXCR4分子背景

C-X-C chemokine receptor type 4 is also known as fusin or CD184 (cluster of differentiation 184), CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R or WHIM. CXCR-4 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. This receptor is one of several chemokine receptors that HIV isolates can use to infect CD4+ T cells. HIV isolates that use CXCR4 are traditionally known as T-cell tropic isolates. Typically, these viruses are found late in infection. It is unclear as to whether the emergence of CXCR4 using HIV is a consequence or a cause of immunodeficiency.CXCR4 is upregulated during the implantation window in natural and hormone replacement therapy cycles in the endometrium, producing, in presence of a human blastocyst, a surface polarization of the CXCR4 receptors suggesting that this receptor is implicated in the adhesion phase of human implantation. SDF-1 and CXCR4 were believed to be a relatively "monogamous" ligand-receptor pair (other chemokines tend to use several different chemokine receptors in a fairly "promiscuous" manner). Recent evidence demonstrates ubiquitin is also a natural ligand of CXCR4. Chronic exposure to THC increased T lymphocyte CXCR4 expression on both CD4+ and CD8+ T lymphocytes. Drugs that block the CXCR4 receptor appear to be capable of "mobilizing" hematopoietic stem cells into the bloodstream as peripheral blood stem cells.

CXCR4分子别名

CXCR4,CD184,Fusin,D2S201E,FB22,HM89,HSY3RR,LAP3,LCR1,LESTR,NPY3R,NPYR,NPYRL,NPYY3R,WHIM

抗体项目交易平台

  • 分子信息
  • 产品列表