FAP
FAP信息
| 英文名称: | Prolyl endopeptidase FAP | 上市药物数量 | 0 |
| 中文名称 | 成纤维细胞激活蛋白α | 临床药物数量 | 29 |
| 靶点别称 | Post-Proline Cleaving Enzyme，FAPalpha，SIMP，Fibroblast Activation Protein， Alpha，Serine Integral Membrane Protease，Prolyl Endopeptidase FAP，EC 3.4.21.26，EC 3.4.14.5，EC 3.4.21.-，DPPIV，FAPA，170 kDa melanoma membrane-bound gelatinase，Seprase，Gelatine degradation protease FAP，Dipeptidyl peptidase FAP，Fibroblast activation protein alpha，APCE，Integral membrane serine protease，Surface-expressed protease，FAP | 最高研发阶段 | 临床二期 |
| 英文名称: | Prolyl endopeptidase FAP |
| 中文名称 | 成纤维细胞激活蛋白α |
| 靶点别称 | Post-Proline Cleaving Enzyme，FAPalpha，SIMP，Fibroblast Activation Protein， Alpha，Serine Integral Membrane Protease，Prolyl Endopeptidase FAP，EC 3.4.21.26，EC 3.4.14.5，EC 3.4.21.-，DPPIV，FAPA，170 kDa melanoma membrane-bound gelatinase，Seprase，Gelatine degradation protease FAP，Dipeptidyl peptidase FAP，Fibroblast activation protein alpha，APCE，Integral membrane serine protease，Surface-expressed protease，FAP |
| 上市药物数量 | 0 |
| 临床药物数量 | 29 |
| 最高研发阶段 | Phase 2 Clinical |
FAP产品列表
- 属性
Protein (11)Beads (1)Cell (1)
- 产品库
在线 (13)
- 物种
Human (8)Cynomolgus (2)Mouse (2)Rat (1)
- 标签
His Tag (6)Fc Tag (2)His Tag & Avi Tag (3)
- 标记
Unconjugated (5)FITC Labeled (2)Biotin-labeled (3)PE Labeled (1)
共 13 项数据
- 1
- 2
FAP分子背景
FAP (also known as seprase) is a Type II transmembrane serine protease. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences. Degrade also gelatin, heat-denatured type I collagen. Also has dipeptidyl peptidase activity, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.
FAP分子别名
FAP,FAPalpha,SIMP,Seprase,APCE
产品评论
bo*****velavigo.com 2025-01-10
0人点赞 我们购买该鼠源蛋白的作用主要是用来免疫和筛选相关的鼠源蛋白复合物。在相关生物化学的检测和结合中，该蛋白有着很强的稳定行。能够有效的鉴别出新的作用蛋白。- bo*****velavigo.com 2025-01-10 0人点赞 ACRO家biotin标记的蛋白，检测信号一般都还很强。我们买这个蛋白主要是用于相关的筛选实验，该蛋白能够有效的筛选出符合预期的蛋白，质量稳定可重复。
- 25********qq.com 2024-12-28 0人点赞 最近购买cynomolgus FAP蛋白用于抗体库筛选，蛋白特异性很不错，目前已成功获得很多个候选抗体，下一步会回购继续亲和力改造，希望能够实验成功。
加载更多
- 分子信息
- 产品列表