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GAD2

GAD2信息

英文名称:Glutamate decarboxylase 2上市药物数量0
中文名称谷氨酸脱羧酶2临床药物数量1
靶点别称EC 4.1.1.15，GAD65，Glutamate Decarboxylase 2 (Pancreatic Islets And Brain， 65kD)，Glutamate Decarboxylase-2 (Pancreas)，EC:4.1.1.15，EC 4.1.1，Glutamate decarboxylase 65 kDa isoform，65 kDa glutamic acid decarboxylase，GAD2，Glutamate Decarboxylase 2，Glutamate Decarboxylase 2 (Pancreatic Islets And Brain， 65kDa)，GAD-65最高研发阶段临床二期
英文名称:Glutamate decarboxylase 2
中文名称谷氨酸脱羧酶2
靶点别称EC 4.1.1.15，GAD65，Glutamate Decarboxylase 2 (Pancreatic Islets And Brain， 65kD)，Glutamate Decarboxylase-2 (Pancreas)，EC:4.1.1.15，EC 4.1.1，Glutamate decarboxylase 65 kDa isoform，65 kDa glutamic acid decarboxylase，GAD2，Glutamate Decarboxylase 2，Glutamate Decarboxylase 2 (Pancreatic Islets And Brain， 65kDa)，GAD-65
上市药物数量0
临床药物数量1
最高研发阶段Phase 2 Clinical

GAD2产品列表

  • 属性

    Protein (1)

  • 产品库

    在线 (1)

  • 物种

    Human (1)

  • 标签

    His Tag (1)

  • 标记

    Unconjugated (1)

共 1 项数据
  • 1

GAD2分子背景

Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the decarboxylation of glutamate to gamma-aminobutyric acid (GABA), the major inhibitory transmitter in higher brain regions, and putative paracrine hormone in pancreatic islets. GAD uses pyridoxal-phosphate (PLP) as a cofactor.Two molecular forms of GAD (65 kDa and 67 kDa) are highly conserved and both are expressed in the CNS, pancreatic islet cells, testis, oviduct and ovary. The isoforms are regionally distributed cytoplasmically in the brains of rats and mice. GAD65 is an ampiphilic, membrane-anchored protein (585 a.a.), and is responsible for vesicular GABA production. GAD67 is cytoplasmic (594 a.a.), and seems to be responsible for significant cytoplasmic GABA production.

GAD2分子别名

GAD2,GAD65,Glutamate decarboxylase 2
  • 分子信息
  • 产品列表