gp130
gp130信息
| 英文名称: | Interleukin-6 receptor subunit beta | 上市药物数量 | 5 |
| 中文名称 | 白细胞介素-6β亚基 | 临床药物数量 | 8 |
| 靶点别称 | IL6ST，Oncostatin-M Receptor Subunit Alpha，CD130，Interleukin-6 Signal Transducer，Interleukin-6 Receptor Subunit Beta，Gp130 Of The Rheumatoid Arthritis Antigenic Peptide-Bearing Soluble Form，CD130 Antigen，Membrane Glycoprotein Gp130，SGP130，IL-6R-Beta，HIES4，Gp130， Oncostatin M Receptor，IL-6RB，GP130，Cytokine Receptor gp130，Interleukin 6 Signal Transducer，Membrane Glycoprotein 130，Interleukin 6 Signal Transducer (Gp130， Oncostatin M Receptor)，CDW130，IL-6 Receptor Subunit Beta，Interleukin Receptor Beta Chain，IL-6R Subunit Beta | 最高研发阶段 | 批准上市 |
| 英文名称: | Interleukin-6 receptor subunit beta |
| 中文名称 | 白细胞介素-6β亚基 |
| 靶点别称 | IL6ST，Oncostatin-M Receptor Subunit Alpha，CD130，Interleukin-6 Signal Transducer，Interleukin-6 Receptor Subunit Beta，Gp130 Of The Rheumatoid Arthritis Antigenic Peptide-Bearing Soluble Form，CD130 Antigen，Membrane Glycoprotein Gp130，SGP130，IL-6R-Beta，HIES4，Gp130， Oncostatin M Receptor，IL-6RB，GP130，Cytokine Receptor gp130，Interleukin 6 Signal Transducer，Membrane Glycoprotein 130，Interleukin 6 Signal Transducer (Gp130， Oncostatin M Receptor)，CDW130，IL-6 Receptor Subunit Beta，Interleukin Receptor Beta Chain，IL-6R Subunit Beta |
| 上市药物数量 | 5 |
| 临床药物数量 | 8 |
| 最高研发阶段 | Approved |
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gp130分子背景
Interleukin-6 receptor subunit beta (IL6ST) is also known as IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130 (gp130), CD130, Oncostatin-M receptor subunit alpha and Il6st,which is single-pass type I membrane protein. IL6ST /gp130 /CD130 can be found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver and found in all the cell lines tested except BaF-B03.The expression of IL-6ST /gp130 is not restricted to IL6-responsive cells. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. IL6ST /CD130 can bind to IL6 /IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduce the signal. IL6ST /GP130 does not bind IL6 and may have a role in embryonic development.
gp130分子别名
IL6ST,gp130,CD130,IL-6RB,IL-6R-beta,CDw130
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