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HVEM

HVEM信息

英文名称:Tumor necrosis factor receptor superfamily member 14上市药物数量0
中文名称肿瘤坏死因子受体超家族成员14临床药物数量0
靶点别称Herpes virus entry mediator A，Herpesvirus entry mediator A，HveA，Tumor necrosis factor receptor-like 2，TR2，CD270，HVEM最高研发阶段临床前
英文名称:Tumor necrosis factor receptor superfamily member 14
中文名称肿瘤坏死因子受体超家族成员14
靶点别称Herpes virus entry mediator A，Herpesvirus entry mediator A，HveA，Tumor necrosis factor receptor-like 2，TR2，CD270，HVEM
上市药物数量0
临床药物数量0
最高研发阶段Preclinical

HVEM产品列表

  • 属性

    Protein (4)Cell (3)

  • 产品库

    在线 (7)

  • 物种

    Human (7)

  • 标签

    His Tag (1)Fc Tag (1)Fc Tag & Avi Tag (1)Mouse IgG Fc Tag (1)

  • 标记

    Unconjugated (3)Biotin-labeled (1)

共 7 项数据
  • 1

HVEM分子背景

Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily. HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D (gD). Two TNF superfamily ligands, including the secreted TNFβ (lymphotoxin α) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LTβR, the receptor for lymphotoxin αβ heterotrimer. The role of the HVEM LIGHT /LTβ receptor ligand pair in immune function and herpesvirus pathobiology remains to be elucidated.

HVEM分子别名

TNFRSF14,ATAR,HVEA,HVEM,LIGHTR,TR2,CD270

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