Integrin alpha D beta 2
Integrin alpha D beta 2信息
| 英文名称: | Integrin alpha-4 | 上市药物数量 | 1 |
| 中文名称 | 整合素-4 | 临床药物数量 | 3 |
| 靶点别称 | CD49D，Integrin alpha-IV，ITGA4，Integrin Subunit Alpha 4，Alpha 4 Subunit Of VLA-4 Receptor，VLA-4 Subunit Alpha，Integrin， Alpha 4 (Antigen CD49D， Alpha 4 Subunit Of VLA-4 Receptor)，CD49 antigen-like family member D，Very Late Activation Protein 4 Receptor， Alpha 4 Subunit，Antigen CD49D， Alpha-4 Subunit Of VLA-4 Receptor，Integrin Alpha-4，269C Wild Type，CD49d Antigen，Antigen CD49D，IA4，Integrin alpha4 | 最高研发阶段 | 批准上市 |
| 英文名称: | Integrin alpha-4 |
| 中文名称 | 整合素-4 |
| 靶点别称 | CD49D，Integrin alpha-IV，ITGA4，Integrin Subunit Alpha 4，Alpha 4 Subunit Of VLA-4 Receptor，VLA-4 Subunit Alpha，Integrin， Alpha 4 (Antigen CD49D， Alpha 4 Subunit Of VLA-4 Receptor)，CD49 antigen-like family member D，Very Late Activation Protein 4 Receptor， Alpha 4 Subunit，Antigen CD49D， Alpha-4 Subunit Of VLA-4 Receptor，Integrin Alpha-4，269C Wild Type，CD49d Antigen，Antigen CD49D，IA4，Integrin alpha4 |
| 上市药物数量 | 1 |
| 临床药物数量 | 3 |
| 最高研发阶段 | Approved |
Integrin alpha D beta 2产品列表
- 属性
Protein (1)
- 产品库
在线 (1)
- 物种
Human (1)
- 标签
His Tag (1)
- 标记
Unconjugated (1)
共 1 项数据
- 1
Integrin alpha D beta 2分子背景
Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Alpha D beta 2, selectively binds ICAM-3 and does not appear to bind ICAM-1. In addition, a soluble form of alpha D beta 2 binds VCAM-1 with greater efficiency relative to ICAM-3. The I domain of alpha D contains a binding site for VCAM-1 since recombinant alpha D I domain binds specifically to VCAM-1.
Integrin alpha D beta 2分子别名
Integrin alpha D beta 2,ITGAD & ITGB2
- 分子信息
- 产品列表