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LGR5

LGR5信息

英文名称:Leucine-rich repeat-containing G-protein coupled receptor 5上市药物数量0
中文名称富含亮氨酸重复序列的G蛋白偶联受体-5临床药物数量2
靶点别称FEX，G Protein-Coupled Receptor 49，GRP49，HG38，G-protein coupled receptor HG38，GPR49，GPR67，G-protein coupled receptor 49，Leucine-rich repeat-containing G-protein coupled receptor 5，LGR5，Leucine Rich Repeat Containing G Protein-Coupled Receptor 5，G-Protein Coupled Receptor 67，Orphan G Protein-Coupled Receptor HG38最高研发阶段临床三期
英文名称:Leucine-rich repeat-containing G-protein coupled receptor 5
中文名称富含亮氨酸重复序列的G蛋白偶联受体-5
靶点别称FEX，G Protein-Coupled Receptor 49，GRP49，HG38，G-protein coupled receptor HG38，GPR49，GPR67，G-protein coupled receptor 49，Leucine-rich repeat-containing G-protein coupled receptor 5，LGR5，Leucine Rich Repeat Containing G Protein-Coupled Receptor 5，G-Protein Coupled Receptor 67，Orphan G Protein-Coupled Receptor HG38
上市药物数量0
临床药物数量2
最高研发阶段Phase 3 Clinical

LGR5产品列表

  • 属性

    Protein (3)

  • 产品库

    在线 (3)

  • 物种

    Human (2)Cynomolgus (1)

  • 标签

    His Tag (2)Fc Tag (1)

  • 标记

    Unconjugated (3)

共 3 项数据
  • 1

LGR5分子背景

LGR5 (also known as GPR49) is a seven-transmembrane protein of the class A Rhodopsin-like family of GPCRs. LGR5 and LGR4 bind the R-spondins with high affinity and mediate the potentiation of Wnt/β-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation. The LGR5/RSPO complex could promote Wnt signalling via the neutralization of two transmembrane E3 ligases, RNF43 and ZNRF3.

LGR5分子别名

LGR5, GPR49, GPR67, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38, Leucine-rich repeat-containing G-protein coupled receptor 5
  • 分子信息
  • 产品列表