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LILRB4

LILRB4信息

英文名称:Leukocyte immunoglobulin-like receptor subfamily B member 4上市药物数量0
中文名称免疫抑制受体LILRB4临床药物数量6
靶点别称CD85k Antigen，Leukocyte immunoglobulin-like receptor 5，Immunoglobulin-like transcript 3，CD85k，CD85 antigen-like family member K，LIR-5，Monocyte inhibitory receptor HM18，ILT-3，Leucocyte Ig-Like Receptor B4，ILT3，LIR5，Leukocyte Immunoglobulin-Like Receptor， Subfamily B (With TM And ITIM Domains)， Member 4，HM18，Leukocyte Immunoglobulin Like Receptor B4最高研发阶段临床二期
英文名称:Leukocyte immunoglobulin-like receptor subfamily B member 4
中文名称免疫抑制受体LILRB4
靶点别称CD85k Antigen，Leukocyte immunoglobulin-like receptor 5，Immunoglobulin-like transcript 3，CD85k，CD85 antigen-like family member K，LIR-5，Monocyte inhibitory receptor HM18，ILT-3，Leucocyte Ig-Like Receptor B4，ILT3，LIR5，Leukocyte Immunoglobulin-Like Receptor， Subfamily B (With TM And ITIM Domains)， Member 4，HM18，Leukocyte Immunoglobulin Like Receptor B4
上市药物数量0
临床药物数量6
最高研发阶段Phase 2 Clinical

LILRB4产品列表

  • 属性

    Protein (12)Cell (2)

  • 产品库

    在线 (12)在研 (2)

  • 物种

    Cynomolgus (3)Mouse (2)Human (9)

  • 标签

    Fc Tag (3)His Tag (4)Mouse IgG Fc Tag (2)His Tag & Avi Tag (2)Fc Tag & Avi Tag (1)

  • 标记

    Unconjugated (7)FITC Labeled (2)Biotin-labeled (3)

共 14 项数据
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LILRB4分子背景

Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 / CD85K contains 2 Ig-like C2-type (immunoglobulin-like) domains. CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. LILRB4 / CD85K is receptor for class I MHC antigens. CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance. LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

LILRB4分子别名

LILRB4,ILT3,LIR5,CD85K,HM18

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