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LRRK2

LRRK2信息

英文名称:Leucine-rich repeat serine/threonine-protein kinase 2上市药物数量0
中文名称富含亮氨酸重复的丝氨酸/苏氨酸蛋白激酶-2临床药物数量8
靶点别称PARK8，LRRK2，Leucine Rich Repeat Kinase 2，Leucine-Rich Repeat Serine/Threonine-Protein Kinase 2，Parkinson Disease (Autosomal Dominant) 8，Augmented In Rheumatoid Arthritis 17，Dardarin，AURA17，RIPK7，ROCO2，Leucine-Rich Repeat Serine-Threonine Protein Kinase-2，DKFZp434H2111，FLJ45829最高研发阶段临床二期
英文名称:Leucine-rich repeat serine/threonine-protein kinase 2
中文名称富含亮氨酸重复的丝氨酸/苏氨酸蛋白激酶-2
靶点别称PARK8，LRRK2，Leucine Rich Repeat Kinase 2，Leucine-Rich Repeat Serine/Threonine-Protein Kinase 2，Parkinson Disease (Autosomal Dominant) 8，Augmented In Rheumatoid Arthritis 17，Dardarin，AURA17，RIPK7，ROCO2，Leucine-Rich Repeat Serine-Threonine Protein Kinase-2，DKFZp434H2111，FLJ45829
上市药物数量0
临床药物数量8
最高研发阶段Phase 2 Clinical

LRRK2产品列表

  • 属性

    Protein (2)

  • 产品库

    在研 (2)

  • 物种

    Human (2)

  • 标签

    His Tag (2)

  • 标记

    Unconjugated (2)

共 2 项数据
  • 1

LRRK2分子背景

LAMPs (lysosome associated membrane proteins) represent a family of glycosylated proteins present predominantly on the membrane of lysosomes whose expression can vary among different tissues, suggesting a separation of functions. LAMP5 is expressed highly and specifically in MLL-r leukemia. LAMP5 is a direct target of the oncogenic MLL-fusion protein. LAMP5 depletion significantly inhibited leukemia cell growth in vitro and in vivo. Functional studies showed that LAMP-5 is a novel modulator of innateimmune pathways in MLL-r leukemias. Downregulation of LAMP5 led to inhibition of NF-κB signaling and increased activation of type-1 interferon signaling downstream of Toll-like Receptor/Interleukin 1 Receptor activation.

LRRK2分子别名

  • 分子信息
  • 产品列表