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MMP-3

MMP-3信息

英文名称:Matrix metalloproteinase 3上市药物数量0
中文名称基质金属蛋白酶-3临床药物数量0
靶点别称CHDS6，STR1，STMY，Matrix Metalloproteinase 3，Matrix metalloproteinase-3，MMP-3，SL-1，STMY1，MMP3，Matrix Metalloproteinase 3 (Stromelysin 1， Progelatinase)，Transin-1，Proteoglycanase，Stromelysin-1，Stromelysin 1，EC 3.4.24.17，EC:3.4.24.17，EC 3.4.24，Matrix Metallopeptidase 3最高研发阶段临床前
英文名称:Matrix metalloproteinase 3
中文名称基质金属蛋白酶-3
靶点别称CHDS6，STR1，STMY，Matrix Metalloproteinase 3，Matrix metalloproteinase-3，MMP-3，SL-1，STMY1，MMP3，Matrix Metalloproteinase 3 (Stromelysin 1， Progelatinase)，Transin-1，Proteoglycanase，Stromelysin-1，Stromelysin 1，EC 3.4.24.17，EC:3.4.24.17，EC 3.4.24，Matrix Metallopeptidase 3
上市药物数量0
临床药物数量0
最高研发阶段Preclinical

MMP-3产品列表

  • 属性

    Protein (1)

  • 产品库

    在线 (1)

  • 物种

    Human (1)

  • 标签

    His Tag (1)

  • 标记

    Unconjugated (1)

共 1 项数据
  • 1

MMP-3分子背景

Matrix metalloproteinase 3 (MMP-3), also known as stromelysin 1 and progelatinase, is encoded by the MMP3 gene. The expression of MMP3 is mainly regulated at the transcriptional level, where gene promoters respond to a variety of stimuli including growth factors, cytokines, carcinogens and proto-oncogene products. MMP-3 degrade II, III, IV, IX and X collagen, proteoglycan, fibronectin, laminin, and elastin. In addition, MMP-3 can also activate other MMPs such as MMP-1, MMP-7 and MMP-9, so MMP-3 plays a key role in connective tissue remodeling. This enzyme is involved in wound repair, atherosclerotic progression, and tumor initiation. Studies of MMP-3 wild type and gene knockout in mice have shown that MMP-3 increases the permeability of the blood-brain barrier after traumatic injury. Nuclear MMP-3 works as a transcription factor and protease.

MMP-3分子别名

CHDS6
  • 分子信息
  • 产品列表