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NOTCH1

NOTCH1信息

英文名称:Neurogenic locus notch homolog protein 1上市药物数量0
中文名称神经源性基因Notch同源蛋白1临床药物数量1
靶点别称Notch Receptor 1，EC 2.1.2.11，Translocation-associated notch protein TAN-1，NEXT，NICD，hN1，NOTCH1，Notch 1，TAN1，Notch (Drosophila) Homolog 1 (Translocation-Associated)，Notch Homolog 1， Translocation-Associated (Drosophila)，Notch Homolog 1， Translocation-Associated，AOVD1，AOS5，Receptor， Notch1，EC 3.4.21.68，Neurogenic locus notch homolog protein 1最高研发阶段临床二期
英文名称:Neurogenic locus notch homolog protein 1
中文名称神经源性基因Notch同源蛋白1
靶点别称Notch Receptor 1，EC 2.1.2.11，Translocation-associated notch protein TAN-1，NEXT，NICD，hN1，NOTCH1，Notch 1，TAN1，Notch (Drosophila) Homolog 1 (Translocation-Associated)，Notch Homolog 1， Translocation-Associated (Drosophila)，Notch Homolog 1， Translocation-Associated，AOVD1，AOS5，Receptor， Notch1，EC 3.4.21.68，Neurogenic locus notch homolog protein 1
上市药物数量0
临床药物数量1
最高研发阶段Phase 2 Clinical

NOTCH1产品列表

  • 属性

    Protein (3)

  • 产品库

    在线 (3)

  • 物种

    Mouse (1)Human (2)

  • 标签

    His Tag (2)Fc Tag (1)

  • 标记

    Unconjugated (3)

共 3 项数据
  • 1

NOTCH1分子背景

NOTCH1 Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The NOTCH1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.

NOTCH1分子别名

NOTCH1,Notch 1,hN1,TAN1

产品评论

  • ch*********harbourbiomed.com 2021-12-14
    2人点赞
    Human NOTCH1 Protein, Fc Tag (MALS verified)
    购买此蛋白用于检测受体和配体之间的结合，建立RBA assay。_x000D_ 此蛋白Elisa检测可以和配体很好的结合，在octet上检测和配体的亲和力也符合文献报道。
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