免费注册

NOTCH2

NOTCH2信息

英文名称:Neurogenic locus notch homolog protein 2上市药物数量0
中文名称神经源性基因座notch同源蛋白-2临床药物数量0
靶点别称N2ECD，NOTCH2，N2ICD，Notch 2，hN2，Neurogenic Locus Notch Homolog Protein 2，Notch (Drosophila) Homolog 2，Notch Homolog 2 (Drosophila)，Notch Homolog 2，HJCYS，AGS2，Receptor， Notch2，Notch Receptor 2最高研发阶段终止
英文名称:Neurogenic locus notch homolog protein 2
中文名称神经源性基因座notch同源蛋白-2
靶点别称N2ECD，NOTCH2，N2ICD，Notch 2，hN2，Neurogenic Locus Notch Homolog Protein 2，Notch (Drosophila) Homolog 2，Notch Homolog 2 (Drosophila)，Notch Homolog 2，HJCYS，AGS2，Receptor， Notch2，Notch Receptor 2
上市药物数量0
临床药物数量0
最高研发阶段Discontinued

NOTCH2产品列表

  • 属性

    Protein (1)

  • 产品库

    在线 (1)

  • 物种

    Human (1)

  • 标签

    Fc Tag (1)

  • 标记

    Unconjugated (1)

共 1 项数据
  • 1

NOTCH2分子背景

Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus . Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation . Positively regulates self-renewal of liver cancer cells .

NOTCH2分子别名

NOTCH2,hN2,N2ECD
  • 分子信息
  • 产品列表