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SDF-1

SDF-1信息

英文名称:C-X-C motif chemokine ligand 12上市药物数量0
中文名称C-X-C基序趋化因子配体12临床药物数量7
靶点别称Pre-B Cell Growth-Stimulating Factor，SDF1B，C-X-C Motif Chemokine Ligand 12，SDF1，SDF-1，Chemokine (C-X-C Motif) Ligand 12，Stromal Cell-Derived Factor 1，CXCL12，HSDF-1，SCYB12，C-X-C Motif Chemokine 12，IRH，TLSF，Chemokine CXCL12，TLSF-A，TLSF-B，SDF-1b，SDF-1a，Intercrine Reduced In Hepatomas，TPAR1，PBSF，HIRH，SDF1A最高研发阶段临床二期
英文名称:C-X-C motif chemokine ligand 12
中文名称C-X-C基序趋化因子配体12
靶点别称Pre-B Cell Growth-Stimulating Factor，SDF1B，C-X-C Motif Chemokine Ligand 12，SDF1，SDF-1，Chemokine (C-X-C Motif) Ligand 12，Stromal Cell-Derived Factor 1，CXCL12，HSDF-1，SCYB12，C-X-C Motif Chemokine 12，IRH，TLSF，Chemokine CXCL12，TLSF-A，TLSF-B，SDF-1b，SDF-1a，Intercrine Reduced In Hepatomas，TPAR1，PBSF，HIRH，SDF1A
上市药物数量0
临床药物数量7
最高研发阶段Phase 2 Clinical

SDF-1产品列表

  • 属性

    Protein (1)

  • 产品库

    在线 (1)

  • 物种

    Human (1)

  • 标签

    His Tag (1)

  • 标记

    Unconjugated (1)

共 1 项数据
  • 1

SDF-1分子背景

Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells

SDF-1分子别名

SDF-1,CXCL12,hSDF-1,IRH,hIRH,PBSF,SDF1,SDF1A,SDF1B

产品评论

  • 18*********163.com 2023-05-16
    0人点赞
    Human SDF-1 / CXCL12 Protein, His Tag
    Human SDF-1在五一回来的时候买的，急用，隔了一天就到了，解了我的燃眉之急。质量也超赞的，和R&D一样用，性价比很高
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