免费注册

Sonic Hedgehog

Sonic Hedgehog信息

英文名称:Sonic Hedgehog Homolog上市药物数量0
中文名称SHH临床药物数量4
靶点别称HHG-1，Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains，ShhNC，Shh N-terminal processed signaling domains，ShhNp，ShhN，Sonic hedgehog protein，Sonic hedgehog protein N-product，Sonic Hedgehog Signaling Molecule，Sonic Hedgehog (Drosophila) Homolog最高研发阶段临床二期
英文名称:Sonic Hedgehog Homolog
中文名称SHH
靶点别称HHG-1，Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains，ShhNC，Shh N-terminal processed signaling domains，ShhNp，ShhN，Sonic hedgehog protein，Sonic hedgehog protein N-product，Sonic Hedgehog Signaling Molecule，Sonic Hedgehog (Drosophila) Homolog
上市药物数量0
临床药物数量4
最高研发阶段Phase 2 Clinical

Sonic Hedgehog产品列表

  • 属性

    Protein (1)

  • 产品库

    在线 (1)

  • 物种

    Human (1)

  • 标签

    His Tag (1)

  • 标记

    Unconjugated (1)

共 1 项数据
  • 1

Sonic Hedgehog分子背景

Sonic hedgehog protein (SHH) is also known as HHG-1, which belongs to the hedgehog family. SHH is expressed in fetal intestine, liver, lung, and kidney and not expressed in adult tissues. Sonic hedgehog protein can be cleavage into sonic hedgehog protein N-product and sonic hedgehog protein C-product by autolysis. SHH binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development. The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity.

Sonic Hedgehog分子别名

SHH,HHG-1,Sonic hedgehog,HLP3,HPE3,SMMCI,TPT,TPTPS
  • 分子信息
  • 产品列表