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TDP-43

TDP-43信息

英文名称:TAR DNA binding protein 43上市药物数量0
中文名称TAR DNA结合蛋白43临床药物数量2
靶点别称TAR DNA-binding protein 43，TARDBP，TAR DNA Binding Protein，TDP43，TAR DNA-Binding Protein-43，ALS10最高研发阶段临床二期
英文名称:TAR DNA binding protein 43
中文名称TAR DNA结合蛋白43
靶点别称TAR DNA-binding protein 43，TARDBP，TAR DNA Binding Protein，TDP43，TAR DNA-Binding Protein-43，ALS10
上市药物数量0
临床药物数量2
最高研发阶段Phase 2 Clinical

TDP-43产品列表

  • 属性

    Protein (1)

  • 产品库

    在线 (1)

  • 物种

    Human (1)

  • 标签

    His Tag (1)

  • 标记

    Unconjugated (1)

共 1 项数据
  • 1

TDP-43分子背景

TDP-43, the transactive response (TAR)-DNA binding Protein with a molecular weight of 43 KDa is encoded by TARDBP gene that located at the chromosome 1. It is a RNA/DNA binding protein that structurally resembles a typical hnRNP protein family member. involved in transcriptional regulation and RNA processing. It is linked to sporadic and familial amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP-43 is predominantly nuclear, but it translocates to the cytoplasm under pathological conditions. Cytoplasmic accumulation, phosphorylation, ubiquitination and truncation of TDP-43 are the main hallmarks of TDP-43 proteinopathies.

TDP-43分子别名

TAR DNA-binding protein 43
  • 分子信息
  • 产品列表