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TIGIT

TIGIT信息

英文名称:T cell immunoglobulin and ITIM domains上市药物数量0
中文名称T细胞免疫球蛋白ITIM结构域临床药物数量37
靶点别称V-Set And Immunoglobulin Domain Containing 9，Washington University Cell Adhesion Molecule，V-Set And Transmembrane Domain Containing 3，WUCAM，DKFZp667A205，FLJ39873，V-set and immunoglobulin domain-containing protein 9，TIGIT，VSIG9，T Cell Immunoreceptor With Ig And ITIM Domains，V-Set And Transmembrane Domain-Containing Protein 3，VSIG9， VSTM3，VSTM3，T-Cell Immunoreceptor With Ig And ITIM Domains最高研发阶段临床三期
英文名称:T cell immunoglobulin and ITIM domains
中文名称T细胞免疫球蛋白ITIM结构域
靶点别称V-Set And Immunoglobulin Domain Containing 9，Washington University Cell Adhesion Molecule，V-Set And Transmembrane Domain Containing 3，WUCAM，DKFZp667A205，FLJ39873，V-set and immunoglobulin domain-containing protein 9，TIGIT，VSIG9，T Cell Immunoreceptor With Ig And ITIM Domains，V-Set And Transmembrane Domain-Containing Protein 3，VSIG9， VSTM3，VSTM3，T-Cell Immunoreceptor With Ig And ITIM Domains
上市药物数量0
临床药物数量37
最高研发阶段Phase 3 Clinical

TIGIT产品列表

  • 属性

    Protein (20)Cell (1)

  • 产品库

    在线 (20)在研 (1)

  • 物种

    Human (8)Cynomolgus / Rhesus macaque (5)Mouse (5)Rat (1)Rabbit (1)Canine (1)

  • 标签

    Fc Tag & Avi Tag (3)Fc Tag (5)His Tag (5)Mouse IgG Fc Tag (3)Mouse IgG Fc Tag & Avi Tag (1)His Tag & Avi Tag (3)

  • 标记

    Biotin-labeled (7)Unconjugated (12)PE Labeled (1)

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TIGIT分子背景

T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

TIGIT分子别名

TIGIT,VSIG9,VSTM3

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