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TNFSF11

TNFSF11信息

英文名称:Tumor necrosis factor ligand superfamily member 11上市药物数量7
中文名称肿瘤坏死因子配体超家族成员11临床药物数量23
靶点别称Osteoclast differentiation factor，TRANCE，TNFSF11，TNF-related activation-induced cytokine，Tumor necrosis factor ligand superfamily member 11，CD254，TNF Superfamily Member 11，Osteoprotegerin Ligand，Receptor Activator Of Nuclear Factor Kappa B Ligand，Tumor Necrosis Factor Superfamily Member 11，ODF，RANKL，OPGL，CD254 Antigen，HRANKL2，TNLG6B，OPTB2，SOdf，RANK Ligand，Tumor Necrosis Factor (Ligand) Superfamily， Member 11，Receptor Activator Of Nuclear Factor Kappa-B Ligand，Tumor Necrosis Factor Ligand 6B最高研发阶段批准上市
英文名称:Tumor necrosis factor ligand superfamily member 11
中文名称肿瘤坏死因子配体超家族成员11
靶点别称Osteoclast differentiation factor，TRANCE，TNFSF11，TNF-related activation-induced cytokine，Tumor necrosis factor ligand superfamily member 11，CD254，TNF Superfamily Member 11，Osteoprotegerin Ligand，Receptor Activator Of Nuclear Factor Kappa B Ligand，Tumor Necrosis Factor Superfamily Member 11，ODF，RANKL，OPGL，CD254 Antigen，HRANKL2，TNLG6B，OPTB2，SOdf，RANK Ligand，Tumor Necrosis Factor (Ligand) Superfamily， Member 11，Receptor Activator Of Nuclear Factor Kappa-B Ligand，Tumor Necrosis Factor Ligand 6B
上市药物数量7
临床药物数量23
最高研发阶段Approved

TNFSF11产品列表

  • 属性

    Protein (9)

  • 产品库

    在线 (9)

  • 物种

    Human (6)Rat (1)Cynomolgus (2)

  • 标签

    His Tag (2)Fc Tag (2)Avi Tag & Fc Tag (1)His Tag & Avi Tag (2)Mouse IgG Fc Tag (1)Tag Free (1)

  • 标记

    Unconjugated (6)Biotin-labeled (3)

共 9 项数据
  • 1

TNFSF11分子背景

Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL, through its ability to stimulate osteoclast formation and activity, is a critical mediator of bone resorption and overall bone density. Some findings also suggestion some cancer cells, particularly prostate cancer cells, can activate an increase in bone remodeling and ultimately increase overall bone production.[17] This increase in bone remodeling and bone production increases the overall growth of bone metastasizes. The overall control of bone remodeling is regulated by the binding of RANKL with its receptor or its decoy receptor, respectively, RANK and OPG.

TNFSF11分子别名

RANKL,CD254,TRANCE,OPGL,ODF

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