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描述/背景（Background）
PD-L1, is a ligand that binds with the receptor PD1, commonly found on T-cells, and acts to block T-cell activation. PD1 expression has been observed in a variety of cancers including melanoma and non-small cell lung cancer. The interaction of PD1/PDL1 is hypothesized to be a possible mechanism for the tumor to escape immune response. A number of checkpoint blockade inhibitors including pembrolizumab and nivolumab have been developed that target the PD1/PDL1 interaction in order to allow T-cells to recognize tumor cells without being deactivated by the tumor.
种属（Host Species）
Rabbit
克隆号（Clone）
5D3
适用方法（Application）
IHC
效价（Property）
1：1000
状态（State）
Liquid
阳性对照（Positive Control）
Human Tonsil Tissues
克隆类型（Clonality）
Monoclonal
分子别名（Synonym）
CD274, PD-L1
研究领域（Research Field）
Cancer Drug Targets
抗体来源（Source）
Rabbit
同种型（Isotype）
IgG
储存（Storage）
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
质量管理控制体系（QMS）
数据展示
质控样本（Control Sample）
Immunohistochemical analysis of paraffin embedded Human tonsil tissue labelled with HCS-S240 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
肿瘤样本（Cancer Sample）
Immunohistochemical analysis of paraffin embedded human cancer tissue labelled with HCS-S240 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
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