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Human CD200 / OX-2 Protein, His Tag

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Qty.
OX2-H5228-1mg (500ug X 2)
¥15120.00
OX2-H5228-100ug
¥2625.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    CD200,MOX1,MOX2,MRC,OX-2,My033

  • 表达区间及表达系统(Source)

    Human CD200, His Tag (OX2-H5228) is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Gly 232 (Accession # AAH22522).

    Predicted N-terminus: Gln 31

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    CD200 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 23.3 kDa. The protein migrates as 35-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method.

  • 纯度(Purity)

    >98% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

数据展示

  • 电泳(SDS-PAGE)

    CD200 SDS-PAGE

    Human CD200, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 98%.

  • 活性(Bioactivity)-ELISA

     CD200 ELISA

    Immobilized Human CD200, His Tag (Cat. No. OX2-H5228) at 2 μg/mL (100 μL/well) can bind Biotinylated Human CD200 R1, Fc,Avitag (Cat. No. CR2-H82F4) with a linear range of 1-31 ng/mL (QC tested).

    Protocol

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背景介绍

CD200 is also known as OX-2 membrane glycoprotein (OX-2), is a type-1 membrane glycoprotein, which contains two immunoglobulin domains (1 Ig-like C2-type (immunoglobulin-like) domain and Ig-like V-type (immunoglobulin-like) domain), and thus belongs to the immunoglobulin superfamily. CD200 / OX-2 is widely expressed in multiple cell types. CD200 interacts with a structurally related receptor (CD200R) expressed mainly on myeloid cells and is involved in regulation of macrophage and mast cell function. OX-2 / CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.

前沿进展

 
药物研发进展
  • 英文全称:

    OX-2 membrane glycoprotein

  • 中文全称:

    OX-2膜糖蛋白

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    1 详情

  • 最高研发阶段:

    临床二期

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