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PE-Labeled Human CLEC12A / MICL / CLL-1 Protein, His Tag (Site-specific conjugation)

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Qty.
CLA-HP2Q3-25tests
¥3675.00
CLA-HP2Q3-200tests
¥22890.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    CLEC12A,MICL,CLL-1,CLL1,DCAL2,DCAL-2,CD371

  • 表达区间及表达系统(Source)

    PE-Labeled Human CLEC12A, His Tag (CLA-HP2Q3) is produced via site-specific conjugation of PE to Human CLEC12A, His Tag under optimal conditions with a proprietary technology. Human CLEC12A, His Tag is expressed from human 293 cells (HEK293). It contains AA His 65 - Ala 265 (Accession # Q5QGZ9-2).

    Predicted N-terminus: Gly

    Request for sequence

  • 蛋白结构(Molecular Characterization)

    CLEC12A Structure

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 27.3 kDa.

  • 偶联(Conjugate)

    PE

    Excitation Wavelength: 488 nm / 561 nm

    Emission Wavelength: 575 nm

  • 应用说明(Application)

    Evaluation of anti-CLEC12A CAR expression by flow cytometry. Please note that this product is NOT compatible to streptavidin detection system.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, 0.5% BSA, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

数据展示

  • 活性(Bioactivity)-FACS

     CLEC12A FACS

    5e5 of anti-CLEC12A/CLL-1 CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human CLEC12A, His Tag (Cat. No. CLA-HP2Q3) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).

    Protocol

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背景介绍

CLEC12A (C-type lectin domain family 12 member A) is also known as CLL1, DCAL2, MICL. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. Evidence of distinct disease propagating stem cells in myelodysplastic syndrome (MDS) has emerged in recent years. The role of CLEC12A in MDS, however, remains to be elucidated. Furthermore, CLEC12A has been proposed as a promising marker of leukaemic stem cells in AML.

前沿进展

 
药物研发进展
  • 英文全称:

    C-Type lectin domain family 12 member A

  • 中文全称:

    C型凝集素结构域家族12成员A

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    19 详情

  • 最高研发阶段:

    临床二期

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