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Mouse GFR alpha-like Protein, His Tag

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GFA-M52H7-100ug
¥3675.00
GFA-M52H7-1mg (250ug X 4)
¥24255.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    GFR alpha like,GFR alpha-like,GFRAL,GRAL

  • 表达区间及表达系统(Source)

    Mouse GFR alpha-like, His Tag (GFA-M52H7) is expressed from human 293 cells (HEK293). It contains AA Gln 20 - Gly 349 (Accession # Q6SJE0-1).

    Predicted N-terminus: Gln 20

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    GFR alpha-like Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 39.0 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method.

  • 纯度(Purity)

    >95% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

数据展示

  • 电泳(SDS-PAGE)

    GFR alpha-like SDS-PAGE

    Mouse GFR alpha-like, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • 活性(Bioactivity)-ELISA

     GFR alpha-like ELISA

    Immobilized Mouse GFR alpha-like, His Tag (Cat. No. GFA-M52H7) at 5 μg/mL (100 μL/well) can bind Human GDF-15, Fc Tag (Cat. No. GD5-H5269) with a linear range of 0.1-2 ng/mL (QC tested).

    Protocol

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背景介绍

GFR alpha-like is also known as GDNF family receptor alpha-like, GFRAL, C6orf144, UNQ9356, PRO34128. Growth differentiation factor-15 (GDF15) is a circulating protein that has been implicated in multiple biological processes, including energy homeostasis, body weight regulation, and cachexia driven by cancer and chronic disease. GDNF family receptor α-like (GFRAL) was recently identified as the neuronal brainstem receptor responsible for mediating the anorectic actions of GDF15. Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.

前沿进展

 
药物研发进展
  • 英文全称:

    GDNF family receptor alpha-like

  • 中文全称:

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    1 详情

  • 最高研发阶段:

    临床一期

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