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Cynomolgus Siglec-9 Protein, His Tag

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SI9-C52H9-100ug
¥3675.00
SI9-C52H9-1mg (500ug X 2)
¥24255.00
合计0件 产品金额¥ 0

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  • 分子别名(Synonym)

    Siglec-9,SIGLEC9,CDw329,CD329

  • 表达区间及表达系统(Source)

    Cynomolgus Siglec-9, His Tag (SI9-C52H9) is expressed from human 293 cells (HEK293). It contains AA Gln 20 - Gly 350 (Accession # XP_005590140.1).

    Predicted N-terminus: Gln 20

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    Siglec-9 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 38.0 kDa. The protein migrates as 55-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method.

  • 纯度(Purity)

    >95% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in 25 mM MES, 150 mM NaCl, pH5.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    Siglec-9 SDS-PAGE

    Cynomolgus Siglec-9, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • 活性(Bioactivity)-ELISA

     Siglec-9 ELISA

    Immobilized Cynomolgus Siglec-9, His Tag (Cat. No. SI9-C52H9) at 10 μg/mL (100 μL/well) on Nickel Coated plate, can bind Neu5Ac(a2-6)GalNAc-PAA-biotin with a linear range of 10-156 ng/mL (QC tested).

    Protocol

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背景介绍

siglec-9 (HGMW-approved symbol SIGLEC9) a member of the sialic acid-binding Ig-like lectin (Siglec) family, which belongs to the immunoglobulin superfamily (IgSF). SIGLEC9 shows a high degree of homology to many members of the siglec family, including siglec-7 (80%), siglec-8 (72%), siglec-5 (65%), and CD33 (64%). This high degree of homology is also conserved in the extracellular Ig-like domains. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains。Siglec-9 with a hydrophobic signal peptide, an N-terminal Ig-likeV-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail.

前沿进展

 
药物研发进展
  • 英文全称:

    Sialic acid-binding Ig-like lectin 9

  • 中文全称:

    唾液酸结合免疫球蛋白样凝集素-9

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    0 详情

  • 最高研发阶段:

    临床前

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